Current detection technologies for circulating tumor cells
نویسندگان
چکیده
منابع مشابه
Detection of Circulating Tumor Cells
The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor ...
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BACKGROUND Circulating biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), are both considered for blood-based mutation detection, but limited studies have compared them in a head-to-head manner. Using KRAS (Kirsten rat sarcoma viral oncogene homolog), we performed such a comparison in patients who underwent surgery for suspected lung cancer. METHODS We recru...
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Circulating tumor cells (CTCs) represent a surrogate biomarker of hematogenous metastases and thus could be considered as a 'liquid biopsy' which reveals metastasis in action. But it is absolutely a challenge to detect CTCs due to their extreme rarity. At present, the most common principle is to take advantage of the epithelial surface markers of CTCs which attach to a specific antibody. Antibo...
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Circulating tumor cells (CTCs) in the blood stream play a critical role in establishing metastases. The clinical value of CTCs as a biomarker for early cancer detection, diagnosis, prognosis, prediction, stratification, and pharmacodynamics have been widely explored in recent years. However, the clinical utility of current CTC tests is limited mainly due to methodological constraints. In this r...
متن کاملMedical Policy Policy Title Circulating Tumor Dna and Circulating Tumor Cells for Cancer Management (liquid Biopsy) [formerly Detection of Circulating Tumor Cells in the Management of Patients
The use of circulating tumor DNA and circulating tumor cells is considered investigational and therefore not covered for all indications. There is insufficient evidence to support a conclusion concerning the health outcomes or benefits associated with this procedure. Cross-reference: MP-2.235 Assays of Genetic Expression in Tumor Tissue as a Technique to Determine Prognosis in Patients with Bre...
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2017
ISSN: 0306-0012,1460-4744
DOI: 10.1039/c6cs00803h